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doi:10.1093/ajcn/86.5.1563S

In addition, this pentadecapeptide Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val is very useful to help wean all patients off of toxic proton pump inhibitor (PPI) medication

William Castle demonstrated that gastric juice contained an "intrinsic factor" which when combined with meat ingestion resulted in absorption of the vitamin in this condition

Complementary metabolic regulation research utilizes mitochondrial-derived peptides like MOTS-c, which activates AMPK signaling and modulates cellular energy homeostasis through mitochondrial-nuclear communication

Patients following vegetarian or vegan diets may need additional B12 supplementation, as this vitamin is primarily found in animal products