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In many cases, PET concentrations in human tissues are extremely low and approach detection limits, necessitating technically demanding workflows [6]

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Notably, microglia from 1LPS- and 4LPS-treated mice exhibit distinct levels of H3K4me1 and H3K27ac, suggesting that epigenetic remodeling plays a key role in trained immunityassociated microglial plasticity (123)

Nelson DB, Tam AL, Mitchell KG, Rice DC , Mehran RJ, Sepesi B, Antonoff MB, Vaporciyan AA, Hofstetter WL