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Cell intrinsic hallmarks

Even peptides that closely mirror those made by the body itself can have different effects when administered like a drug, Eileen Kennedy says

When NNMT depletes SAM in adipocytes, epigenetic regulation is disrupted potentially locking in gene expression patterns that favor energy storage over expenditure

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Its inhibition at the tissue level without systemic suppression represents a pharmacologically favorable profile for research applications where inflammation is driving local tissue damage