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Notably, no significant increases in plasma or urine levels of NAD+ or its metabolites were observed within the first 2 hours of infusion, indicating rapid and complete tissue uptake and/or metabolism (at least for the first 2 hours) (10)

High B12 is a marker, not a cause

Potential interaction with neurotransmitter balance pathways

And on your most recent one on the protein, you talk about leucine and how so many of these sort of health-oriented individuals are taking leucine and theyre also taking rapamycin

The handful of studies sometimes cited as human evidence are largely case reports or small, uncontrolled pilot studies