Acknowledgements We appreciate the support from the National Natural Science Foundation of China (82071676, 81703492)
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Increased expression of PGC-1 is associated with increased expression of nuclear respiratory factor-1 (Nrf-1) and Nrf-2 [70]
Detoxification and breaking down substances: Methylation is essential in the nervous system, in the production and breakdown of neurotransmitters, and in detoxifying some specific environmental toxicants such as arsenic
Meanwhile, O-GlcNAcylation is linked to neurogenesis [30], axonal and dendritic growth and function [31, 32], as well as the regulation of neuronal metabolism [33], cognitive function [34, 35], inflammatory activation and stress response of astrocytes [35, 36]