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require documentation of indication, dosing, and clinical response Biologics (IL-12/23 inhibitor): Ustekinumab (Stelara, J3357) FDA-approved for moderate-to-severe CD

For an 8-week protocol, that is typically 2 vials of KLOW, 1 bottle of bacteriostatic water, 56 syringes, and 112 swabs

Thrombus formation and the subsequent activation of the coagulation cascade with final generation of fibrin is facilitated by the mCRP-mediated enhancement of tissue factor on the endothelial cell surface, platelet aggregation and thrombus growth (207, 208) (Figure 7)

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HLCs are an excellent patient and tissue specific disease model for many liver diseases including those with an underlying genetic etiology