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Two different selenium-dependent iodothyronine deiodinases (DIOs type 1 and 2) can deiodinate T 4 , thus increasing circulating T 3 , while a third iodothyronine deiodinase (DIO type 3) can convert both T 3 and T 4 to inactive metabolites ( Figure 3 ) (10, 11)

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This is because injections of TB4 into the hearts of mice (both injured and uninjured) basically kick-started repair processes and made the epicardium (the outermost layer of the heart) behave as it does in embryonic development