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In fact, by age 65, there is a full 50% reduction in our glutathione levels

Their mechanisms are complementary rather than redundant

Similar content being viewed by others Log in or create a free account to read this content Gain free access to this article, as well as selected content from this journal and more on nature.com or Abbreviations AA: arachidonic acid ACC1: acetyl-CoA carboxylase alpha ACSF2: andacyl-CoA synthetase family member 2 ACSL4: acyl-CoA synthetase long-chain family member 4 AOA: aminooxyacetic acid AKF: acute kidney failure ATP5G3: ATP synthase F0 complex subunit C3 BSO: buthionine sulfoximine BHT: butylated hydroxytoluene CARS: cysteinyl-tRNA synthetase CHAC1: cation transport regulator-like protein 1 COX-2: cyclooxygenase-2 CS: citrate synthase CSSG: cysteine-glutathione disulfide DAMP: damage-associated molecular pattern molecule DMT1: divalent metal transporter 1 ER: endoplasmic reticulum Fe3+: ferric iron Fe2+: ferrous iron FIN: ferroptosis-inducing agents FLT-3: fms-like tyrosine kinase 3 FTH1: ferritin heavy chain 1 FTL: ferritin light chain GPX4: glutathione peroxidase 4 GSH: glutathione HMGB1: high mobility group box 1 HD: Huntingtons disease HETE: hydroxyeicosatetraenoic acid HO-1: heme oxygenase-1 HPETE: hydroperoxyeicosatetraenoic acid HSF-1: heat shock factor-1 HSPB1: heat shock protein beta-1 HCC: hepatocellular carcinoma IREB2: iron-responsive element-binding protein 2 JNK: c-Jun NH 2 -terminal kinase Keap1: Kelch-like ECH-associated protein 1 LOX: lipoxygenases LPCAT3: lysophosphatidylcholine acyltransferase 3 MAPK: mitogen-activated protein kinase MDM2: murine double minute-2 MEFs: mouse embryonic fibroblasts NADPH: nicotinamide adenine dinucleotide phosphate NAPQI: N -acetyl- p -benzoquinone imine NOX: NADPH oxidase NRF2: nuclear factor erythroid 2-related factor 2 OLs: oligodendrocytes PDAC: pancreatic ductal adenocarcinoma PGSK: phen green SK PKC: protein kinase C PPP: pentose phosphate pathway PTGS: prostaglandin-endoperoxide synthase PUFAs: polyunsaturated fatty acids PVL: periventricular leukomalacia RCD: regulated cell death ROS: reactive oxygen species RPL8: ribosomal protein L8 RSLs: Ras-selective lethal small molecules SCP2: sterol carrier protein 2 TFR1: transferrin receptor 1 TTC35: tetratricopeptide repeat domain 35 VDAC: mitochondrial voltage-dependent anion channel

Supplementary Figure 4 Effect of cordycepin on eryptosis levels of nave and P

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