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Anecdotal reports suggest administering reduced dosages over cycles lasting 8-12 weeks

We identified key regions in the p53 transactivation domain (TAD) involved in FOXO4 binding and designed an optimized peptide inhibitor (CPP-CAND) with improved cell permeability

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To check this, we incubated starved the gsh1 -mutant cells in SD-media to which we added 0 M, 0.25 M or 2.5 M glutathione