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According to meta-analysis data, hypothyroidism occurs in about 3.8% of patients treated with anti-CTLA-4, 3.9% with anti-PD-L1, 7.0% with anti-PD-1, and 13.2% with combination therapy

By incorporating cells that retain the molecular and functional features of the native tissue, these platforms allow researchers to reproduce patient specific disease mechanisms and treatment responses in vitro

doi: 10.1046/J.1525-1373.2000.22308.X 249 XuLHuangGCongYYuYLiY