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The FDAs regulatory proposal only suggests one nicotine addiction warning, and Wackowski aims to develop and pilot test a series of warnings that may be appropriate for e-cigarettes in a new research project funded by the FDAs Center for Tobacco Products

However, epidemiological studies assessing Swedish smokeless tobacco, which exposes users to nicotine without combustion products, generally have not found an increased risk of myocardial infarction or stroke among users, but suggest that nicotine might contribute to acute cardiovascular events, especially in those with underlying coronary heart disease

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