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22 Building on extensive evidence, particularly the established relationship between cigarette smoking, GPR15 upregulation, and T-cell function and trafficking, we hypothesized that GPR15 + T cells play a pivotal role in mediating the differential impact of cigarette smoke on the pathogenesis of CD and UC

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Since the brain forms new connections between existing cells rather than growing new ones, nicotine use can hinder this synaptic formation, impacting cognitive and social abilities

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