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The VMN mainly receives neuronal projections from the ARC, and projects their axons to the ARC, DMN and LHA, as well as brainstem regions

5-ALA (5-Aminolevulinic Acid) A naturally occurring amino acid that is a precursor in the heme biosynthesis pathway

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NAD+ and NMN for Cellular Repair and Energy NAD+ (nicotinamide adenine dinucleotide) is a molecule that plays a critical role in mitochondrial function, DNA repair, and cellular energy metabolism

As such, they are typically reserved for younger patients without cognitive impairment, given their significant risk of neuropsychiatric and cognitive side effects [88]