As people age, they start to produce less glutathione
GSH redox cycle The formation of excessive amounts of reactive O 2 species (ROS), including peroxide (H 2 O 2 ) and superoxide anions (O 2 ) is toxic to the cell
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Within the brain, DSIP is particularly abundant in the hypothalamus, hippocampus, and limbic regions, where it interacts with multiple peptide and non-peptide mediators, including corticotropin-like intermediate peptide (CLIP), adrenocorticotrophic hormone (ACTH), melanocyte-stimulating hormone (MSH), and melanin-concentrating hormone (MCH)
In this work, we provide the structural basis for the functional role of heparin-binding in HGF-induced c-MET activation