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It also imitates GIP (glucose-dependent insulinotropic peptide), a hormone released in the small intestine

Paraesthesia (pins and needles) in the hands and feet often improves within two to four weeks, though complete resolution may take several months

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While highly informative, these approaches frequently fail to capture the influence of systemic or extracellular signals such as estrogen [6] or glucocorticoids [7]