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Mast Cell Mediators Mast cell activation syndrome causes repeated bouts of anaphylaxis a life-threatening allergic reaction that usually occurs within seconds of exposure to a trigger

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The endosomal sorting complexes required for transport (ESCRT) machinery, including ESCRT-I and ESCRT-II complexes, initiate the budding process at the endosomal membrane, leading to the formation of intraluminal vesicles (ILVs) within MVBs (Fig

DBS sample collection may contribute to this development

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