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Among different ROS a prominent position is attributed to H 2 O 2 , being the diffusible second messenger that serves as signaling molecule in redox processes [123]

Translocation of phosphorylated-JNK (p-JNK) to the mitochondria enhances mitochondrial oxidative stress in mouse and humans (Xie et al., 2014

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Atherosclerotic cardiovascular disease (ASCVD), including coronary heart disease, ischemic stroke, and peripheral arterial disease, accounts for a substantial portion of this global burden