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Furthermore, we believe that the brain network changes and alterations in neurotransmission that are characteristic of bipolar disorder disrupt brainbody signaling in ways that may in the future allow for novel therapeutic methodologies that reverse the autonomic, neuroendocrine, and immune systems that are characteristic of the disorder and that almost certainly contribute to the high degree of medical morbidity observed in bipolarity

Mitochondria serve as the factory for cellular ROS production, mainly through synthesis in the ETC

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Nitric Oxide System Modulation BPC-157 interacts extensively with the nitric oxide system, influencing both constitutive and inducible nitric oxide synthase enzymes

Three such factors can be postulated