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A schematic model illustrating how GPR15 differentially regulates the effects of cigarette smoke exposure on CD and UC In TNBS-induced CD-like colitis, cigarette smoke exposure upregulates GPR15 expression on T cells, driving their differentiation into Th17 cells and exacerbating disease progression

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[66] Agricultural impacts and control [edit] Because it cannot compete with established plants, great mullein is no longer considered a serious agricultural weed and is easily crowded out in cultivation, [19] except in areas where vegetation is sparse to begin with, such as Californian semidesertic areas of the eastern Sierra Nevada in the USA

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