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However, LPA exists as a mixture of several fatty acids in vivo condition: unsaturated fatty acids (16:1, 18:1, 18:2 and 20:4) and saturated fatty acids (16:0, 18:0) (23)

Those with naturally high NNMT activity might respond more dramatically to inhibition, while those with lower baseline activity might see more modest effects

The regulatory mechanisms of mitochondrial dynamics are complex and involve multiple proteins and signaling pathways

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The 2025 review in the International Journal of Molecular Sciences represents the most comprehensive English-language synthesis of this body of research to date