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Let's get down into how this goes down in our bodies: Salivary Glands - One of the ways it does this is by reducing saliva production, which leads to a dry mouth sensation

Likewise, in Omaiye et al

The CYP2D enzyme family is a well-documented major metabolizer of antidepressants, including desipramine, doxepin, imipramine, maprotiline, mianserin, nortriptyline, protriptyline, and trimipramine (168)

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Because the leaves are still connected to the stalk, they take longer to dry out, and this often results in stalk-cut tobaccos offering a more rich and earthy flavor profile that's beloved for its use as cigar binders and wrappers