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Altogether, these experimental data reveal that circadian disruption affects multiple BC-related hallmarks including immunosuppression, chronic inflammation, altered hormone receptor expression, and dysregulated cell proliferation 204

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Specifically, demethylation of the NRF2 gene promoter region can activate NRF2 expression, enhancing the binding of transcription factors and regulatory proteins to the promoter, thereby increasing the transcription and protein expression of NRF2

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