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Although their biological functions were initially unclear, interest increased when oleamide was identified as an endogenous sleep-inducing molecule in mammalian cerebrospinal fluid 10

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Encouraging the optimization of sleep, joint protection through the proper amount of regular physical exercise (low impact and low resistance), weight control, avoidance of substance use (e.g., alcohol, nicotine), and the consumption of a healthy diet can decrease pain, injuries, and fatigue and support mobility and functionality

doi: 10.1371/journal.pone.0056337