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Among the changes finalized in that rule was an amendment to 42 CFR 411.353(d) to reflect an updated cross-reference to the definition of timely basis at 42 CFR 1003.110 (previously 1003.101), as updated by 81 FR 88334 on December 7, 2016

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Time of day significantly impacts oxidation-reduction reactions in the brain [51,52,53], which may influence the efficacy of antioxidant therapeutics in the treatment of neurologic and psychiatric conditions