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On the other hand, pathophysiological features exhibited the association between mitochondrial dysfunction, decreased activity of complex I and complex IV of the electron transport chain, and the glutathione system in MS [23]

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Another organ with low activity of Sorbitol dehydrogenase is the kidney, resulting in the occurrence of Diabetic Nephropathy

Mechanisms: Depending on their structure and target, peptides may: Bind to specific cell receptors to trigger cellular responses

Thereafter, the ubisemiquinone intermediate can either react with the oxygen molecule and produce the superoxide anion radicals or oxidize further to the fully oxidized ubiquinone that does not react with oxygen