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Because chronic inflammation is strongly associated with metabolic dysfunction, this mechanism has generated interest among researchers studying metabolic disease

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It is known that mTOR signaling is robustly upregulated in conditions of chronic inflammation and in these situations, rapamycin therapy seems to be efficient [66]

The latter results have encouraged the clinical evaluation of HGF (VM-202) gene transfer in human trials for neuropathic diabetic pain (NCT01475786) with the encouraging outcome of a 3-month pain relief period (Kessler et al., 2015)

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