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It formally characterises DSIP as a still unresolved riddle acknowledging that no specific DSIP receptor has been confirmed, that the existence of DSIP-like endogenous peptides distinct from DSIP itself may account for a substantial proportion of DSIP-like immunoreactivity data, and that the most robust SWS-promoting activity in rodent studies has been demonstrated for synthetic DSIP structural analogues rather than native DSIP itself

Conversely, insufficient free radical activity can impair the immune response and disrupt cellular signaling [14]

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"Dysregulation of Astrocytic Glutamine Transport in Acute Hyperammonemic Brain Edema"